Tyro/Axl/Mer Activation Antibody Sampler Kit #18350
Product Information
Kit Usage Information
Protocols
- 4319: Western Blotting, Immunoprecipitation (Agarose), Immunofluorescence, Flow
- 5585: Western Blotting, Immunoprecipitation (Magnetic)
- 5724: Western Blotting
- 7074: Western Blotting
- 8661: Western Blotting, Immunoprecipitation (Agarose), Immunohistochemistry (Paraffin), Immunofluorescence, Flow
- 44463: Western Blotting, Immunoprecipitation (Agarose)
- 67202: Western Blotting, Immunohistochemistry (Paraffin), Immunofluorescence
Product Description
The Tyro/Axl/Mer Activation Antibody Sampler Kit provides an economical means of detecting the activation of TAM family members using phospho-specific and control antibodies. The kit includes enough antibodies to perform two western blot experiments with each primary antibody.
Background
Axl, Mer and Tyro3 are three members of the TAM family receptor tyrosine kinase that share a common NCAM (neural adhesion molecule)-related extracellular domain and a conserved intracellular tyrosine kinase domain. These receptors bind common homologous vitamin K dependent protein GAS6 and protein S to activate downstream signaling pathways (1). TAM family receptors are involved in the development of immune, nervous, vascular and reproductive systems, autoimmune disease, cancer drug resistance and tumor immunity response (2-5). Axl (Tyr698), Axl (Tyr702), Mer Tyr(749) and Tyro3 (Tyr681) are conserved autophosphorylation sites located in the activation loop of the respective tyrosine kinase domains. Phosphorylation at these sites is required for full kinase activation of each of the corresponding receptors (6,7).
- Rothlin, C.V. et al. (2015) Annu Rev Immunol 33, 355-91.
- Burstyn-Cohen, T. (2017) Int J Dev Biol 61, 215-24.
- Bellan, M. et al. (2016) Int J Mol Sci 17, pii: E1807.
- Schoumacher, M. and Burbridge, M. (2017) Curr Oncol Rep 19, 19.
- Akalu, Y.T. et al. (2017) Immunol Rev 276, 165-77.
- Ling, L. et al. (1996) J Biol Chem 271, 18355-62.
- Onken, J. et al. (2017) Oncotarget 8, 50403-14.
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