R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.
VMS1 (D10E6) Rabbit mAb #5937
Filter:
- WB
Supporting Data
| REACTIVITY | M |
| SENSITIVITY | Endogenous |
| MW (kDa) | 100 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- M-Mouse
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Protocol
Specificity / Sensitivity
VMS1 (D10E6) Rabbit mAb detects endogenous levels of total VMS1 protein.
Species Reactivity:
Mouse
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly332 of mouse VMS1 protein.
Background
Mitochondria are membrane-bound subcellular organelles critical to many functions in eukaryotic cells (1). Several mechanisms have been found to play a role in mitochondria quality control (2). A recent study identified mitochondria-associated protein degradation as one such mechanism (1,2). The study showed that VMS1 (VCP/Cdc48-associated mitochondrial stress-responsive) interacts with VCP/Cdc48 and Npl4, two components in the endoplasmic reticulum-associated protein degradation pathway, and mediates the degradation of damaged mitochondrial proteins under stress conditions (1). Defective VMS1 compromises mitochondrial functions and cell viability (1).
限制使用
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For Research Use Only. Not For Use In Diagnostic Procedures.
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