R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.
Vitronectin (F8D3L) Rabbit mAb #53507
Filter:
- IHC
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | |
| Source/Isotype | Rabbit IgG |
Application Key:
- IHC-Immunohistochemistry
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Immunohistochemistry (Paraffin) | 1:100 - 1:400 |
Storage
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Protocol
Specificity / Sensitivity
Vitronectin (F8D3L) Rabbit mAb recognizes endogenous levels of total vitronectin protein.
Species Reactivity:
Human
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Glu133 of human vitronectin protein.
Background
Vitronectin (VTN) is a multidomain adhesive glycoprotein synthesized mostly in the liver and secreted to blood plasma and extracellular matrix (ECM) (1,2). The protein has an N-terminal SMB fragment mediating binding to PAI-1 and UPAR, followed by an RGD region mediating its interaction with integrins, and C-terminal hemopexin-like domains mediating its interaction with various ECM components such as collagens, tenascins, and plasminogen (2,3). VTN has been implicated as a regulator of many diverse physiological processes, including coagulation, complement-dependent immune response, cell attachment and spreading, angiogenesis, hemostasis, and vascular remodeling (4-6). Increased VTN expression promotes cancer cell migration, adhesion, and metastasis in neuroblastoma, ovarian cancer, and breast cancer cells (7-9).
- Schvartz, I. et al. (1999) Int J Biochem Cell Biol 31, 539-44.
- Felding-Habermann, B. and Cheresh, D.A. (1993) Curr Opin Cell Biol 5, 864-8.
- Pellegrini, A. and Pietrocola, G. (2024) Microorganisms 12, 1385. doi: 10.3390/microorganisms12071385.
- Leavesley, D.I. et al. (2013) IUBMB Life 65, 807-18.
- Li, R. et al. (2014) J Vasc Res 51, 110-7.
- Preissner, K.T. and Seiffert, D. (1998) Thromb Res 89, 1-21.
- Burgos-Panadero, R. et al. (2019) BMC Cancer 19, 479.
- Yoshimura, A. et al. (2018) BMC Cancer 18, 1065.
- Bera, A. et al. (2020) PLoS One 15, e0242141.
限制使用
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For Research Use Only. Not For Use In Diagnostic Procedures.
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