R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.
VAMP5 (F9Y8C) Rabbit mAb #17055
Filter:
- WB
- IP
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 13 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Simple Western™ | 1:10 - 1:50 |
| Immunoprecipitation | 1:50 |
Storage
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Protocol
Specificity / Sensitivity
VAMP5 (F9Y8C) Rabbit mAb recognizes endogenous levels of total VAMP5 protein.
Species Reactivity:
Human
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human VAMP5 protein.
Background
Vesicle-associated membrane protein 5 (VAMP5), also known as myobrevin, is a member of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) protein family, preferentially expressed in skeletal muscle and heart, with increased expression during myogenesis (1). While full functionality of VAMP5 is unknown, it has been shown to mediate exosome release through its interaction with SNAP47, syntaxin1, or syntaxin4 (2). VAMP5 has also been shown to promote Fcγ receptor-mediated phagocytosis and may play a role in regulating macrophage phagosome maturation (3). Plasma levels of VAMP5 are downregulated in Alzheimer’s disease (AD), identifying the protein as a potential blood biomarker for AD when paired with other key differentially expressed proteins (4).
限制使用
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For Research Use Only. Not For Use In Diagnostic Procedures.
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