R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.
UT-B/SLC14A1 (E3S8J) Rabbit mAb #44897
Filter:
- WB
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 28-65 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Protocol
Specificity / Sensitivity
UT-B/SLC14A1 (E3S8J) Rabbit mAb recognizes endogenous levels of total UT-B/SLC14A1 protein.
Species Reactivity:
Human
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala380 of human UT-B/SLC14A1 protein.
Background
Urea transporter B (UT-B, also known as UT1) is encoded by the SLC14A1 gene (1). Urea transporters (UTs) are multipass membrane proteins that transport urea down a concentration gradient. Urea is an organic compound composed of two amino groups and a linked carbamoyl group. Urea is a metabolic waste product of the liver and is excreted via the kidney. UT-B/SLC14A1 was first cloned from human erythrocytes (2). UT-B is not only expressed in endothelial cells of the renal medulla but is also expressed in other organs, including the brain, heart, and pancreas, suggesting broad physiological functions. In the brain, UT-B may be expressed in astrocytes to maintain urea concentrations in the central nervous system. Animals lacking UT-B exhibit depression-like behaviors, suggesting that regulation of urea levels in the brain may be important for proper neuronal function (3).
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For Research Use Only. Not For Use In Diagnostic Procedures.
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