UBASH3B (E1A8Y) Rabbit mAb #19217

Ubiquitin-associated and SH3 domain-containing protein B (UBASH3B) is a ubiquitously expressed protein that negatively regulates signaling cascades governed by multiple tyrosine kinases. UBASH3B is a modular protein that contains an N-terminal UBA domain that can interact with ubiquitin, a central SH3 domain that mediates protein-protein interactions, and an evolutionarily conserved C-terminal phosphatase domain. Indeed, research studies have shown that UBASH3B interacts with Bcr-Abl and negatively regulates its kinase activity through a mechanism involving dephosphorylation (1). UBASH3B also plays a pivotal role in the adaptive immune response by negatively regulating the activity of key proximal signaling proteins downstream of the T cell receptor (TCR) (2-4). Research studies have also positioned UBASH3B as an oncogenic protein in the context of triple-negative breast cancer, where its overexpression promotes enhanced EGFR stability via protection from c-Cbl-mediated ubiquitination (5,6).