TRIM8 (F3C3T) Rabbit mAb #85434

Tripartite motif-containing protein 8 (TRIM8) is a RING E3 ubiquitin ligase and member of the TRIM family (1). It was originally termed glioblastoma-expressed RING-finger protein (GERP), encoded by a gene found on a chromosomal region characterized by frequent loss of heterozygosity in glioblastoma (2). The importance of TRIM8 in cancer and other pathological conditions has been described (reviewed in 3,4). Interestingly, TRIM8 has both suppressive and oncogenic activities in cancer. As a tumor suppressor, TRIM8 has the capacity to act in a positive feedback loop to enhance p53 function. TRIM8 is induced by p53 and leads to p53 stabilization by degrading MDM2 (5). In non-small cell lung cancer, TRIM8 functions as a tumor suppressor by targeting MYOF for degradation (6). Other studies illustrated that TRIM8 plays a role in promoting cell proliferation and invasion. TRIM8 regulates cytokine signaling through multiple mechanisms, including inhibition of SOCS1, a suppressor of cytokine signaling (7,8), potentiating TNF-α signaling, and promoting NF-κB activation by targeting TAK1 for K63-linked ubiquitination (9). TRIM8 also interacts with PIAS3, resulting in enhanced STAT3 signaling (10). In ovarian cancer, TRIM8 promotes proliferation by targeting VDAC2 for ubiquitination and degradation (11). In Ewing's sarcoma, TRIM8 promotes survival by targeting the driver fusion EWS/FLI for degradation (12).