R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.
TRIM21 (F6K7J) Rabbit mAb #74400
Filter:
- WB
- IP
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 50 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:50 |
Protocol
Specificity / Sensitivity
TRIM21 (F6K7J) Rabbit mAb recognizes endogenous levels of total TRIM21 protein.
Species Reactivity:
Human
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human TRIM21 protein.
Background
Tripartite motif-containing protein 21 (TRIM21) is a cytosolic antiviral protein that is induced by interferons (IFNs) and acts as a cytosolic IgG receptor (1,2). TRIM21 is an activator of the innate immune system and targets antibody-bound virions to the proteasome via its E3 ubiquitin ligase activity, leading to degradation of the virions in the cytosol (3,4). Interestingly, TRIM21 has also been shown to negatively regulate pathogen-induced IFN production through the polyubiquitin-mediated degradation of multiple targets, including IRF3, IRF7, and DDX41 (5-7).
- Keeble, A.H. et al. (2008) Proc Natl Acad Sci USA 105, 6045-50.
- Sjöstrand, M. et al. (2013) J Immunol 191, 3753-63.
- McEwan, W.A. et al. (2013) Nat Immunol 14, 327-36.
- Mallery, D.L. et al. (2010) Proc Natl Acad Sci USA 107, 19985-90.
- Higgs, R. et al. (2008) J Immunol 181, 1780-6.
- Young, J.A. et al. (2011) J Biol Chem 286, 6521-31.
- Zhang, Z. et al. (2013) Nat Immunol 14, 172-8.
限制使用
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For Research Use Only. Not For Use In Diagnostic Procedures.
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