Cat. # | Size | Price | Inventory |
---|---|---|---|
85535S | 1 Kit |
REACTIVITY | H M R |
Product Includes | Quantity | Isotype | |||
---|---|---|---|---|---|
Tau (D3C7I) Rabbit mAb (BSA and Azide Free) | 100 µg | Rabbit IgG | |||
Tau (D1M9X) XP® Rabbit mAb (BSA and Azide Free) 29384 | 100 µg | Rabbit IgG |
Product Information
Tau is a heterogeneous microtubule-associated protein that promotes and stabilizes microtubule assembly, especially in axons. Six isoforms with different amino-terminal inserts and different numbers of tandem repeats near the carboxy terminus have been identified, and tau is hyperphosphorylated at approximately 25 sites by Erk, glycogen synthase kinase-3 (GSK-3), and CDK5 (1,2). Phosphorylation decreases the ability of tau to bind to microtubules. Neurofibrillary tangles are a major hallmark of Alzheimer's disease (AD); these tangles are bundles of paired helical filaments (PHFs) composed of hyperphosphorylated tau. In particular, phosphorylation at Ser396 by GSK-3 or CDK5 destabilizes microtubules. Furthermore, research studies have shown that inclusions of tau are found in a number of other neurodegenerative diseases, collectively known as tauopathies (1,3).
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