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Total Survivin Matched Antibody Pair #87112

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  • ELISA
ELISA Image 1: Total Survivin Matched Antibody Pair
Data using Total Survivin Matched Antibody Pair #87112 are shown. The two antibodies function as a capture-target-detection sandwich (#83711 and #56622, respectively) to detect endogenous protein expression in HeLa cells.
1/1

To Purchase # 87112

Supporting Data

REACTIVITY H Mk
Application Key:
  • ELISA-ELISA 
Species Cross-Reactivity Key:
  • H-Human 
  • Mk-Monkey 
  • Product Includes
Product IncludesQuantityIsotype
Survivin (6E4) Mouse mAb (BSA and Azide Free) #83711100 µgMouse IgG1
Survivin (71G4B7) Rabbit mAb (BSA and Azide Free) #56622100 µgRabbit IgG

Product Information

Product Usage Information

Matched Antibody Pairs consist of capture and detection antibodies that bind to non-overlapping epitopes. For specific identification of the capture and detection antibodies in this pair, please refer to the data figure caption. Optimal dilutions/concentrations should be determined by the end user.

Formulation

Supplied in 1X PBS (10 mM Na2HPO4, 3 mM KCl, 2 mM KH2PO4, and 140 mM NaCl (pH 7.8)). BSA and Azide Free.

Storage

Store at -20ºC. This product will freeze at -20ºC so it is recommended to aliquot into single-use vials to avoid multiple freeze/thaw cycles. A slight precipitate may be present and can be dissolved by gently vortexing. This will not interfere with antibody performance.

Product Description

The Total Survivin Matched Antibody Pair is ideal for use with immunoassay technologies and high-throughput ELISA platforms requiring antibody pairs with specialized or custom antibody labeling. Labels include fluorophores, lanthanides, biotin, and beads. Platforms requiring conjugated Matched Antibody Pairs include MSD, Quanterix Simoa, Alpha Technology (AlphaScreen, AlphaLISA, LANCE, HTRF), and Luminex.

Learn how Matched Antibody Pairs move your projects forward, faster at cst-science.com/matched-antibody-pairs.

Background

Survivin is a 16 kDa anti-apoptotic protein highly expressed during fetal development and cancer cell malignancy (1). Survivin binds and inhibits caspase-3, controlling the checkpoint in the G2/M-phase of the cell cycle by inhibiting apoptosis and promoting cell division (2,3). This regulatory process requires the phosphorylation of survivin at Thr34 by p34 cdc2 kinase (4). Gene targeting using a Thr34 phosphorylation-defective survivin mutant, as well as antisense survivin, have been shown to inhibit tumor growth (5,6).

Database Links

UniProt ID: O15392


Entrez-Gene Id: 332


限制使用

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For Research Use Only. Not For Use In Diagnostic Procedures.
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