TNFRSF17/BCMA Antibody #47988
Filter:
- WB
- IP
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 18, 23 |
| SOURCE | Rabbit |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:50 |
Storage
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Protocol
Specificity / Sensitivity
TNFRSF17/BCMA Antibody recognizes endogenous levels of total TNFRSF17/BCMA protein.
Species Reactivity:
Human
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu115 of human TNFRSF17/BCMA protein. Antibodies are purified by protein A and peptide affinity chromatography.
Background
B cell maturation antigen (BCMA/TNFRSF17/CD269) is a transmembrane glycoprotein and member of the TNFR superfamily (1). BCMA expression is largely restricted to the B cell lineage. Pro-survival signaling through this receptor plays a pivotal role in humoral immunity by regulating B cell maturation and plasma cell differentiation upon binding its ligands, BAFF and APRIL (2-6). BCMA is expressed in a number of B cell malignancies and has garnered much attention as a novel therapeutic target for the treatment of multiple myeloma due to its selective and elevated expression on the cell surface of malignant plasma cells (7-10).
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- Chiu, A. et al. (2007) Blood 109, 729-39.
- Avery, D.T. et al. (2003) J Clin Invest 112, 286-97.
- O'Connor, B.P. et al. (2004) J Exp Med 199, 91-8.
- Darce, J.R. et al. (2007) J Immunol 178, 5612-22.
- Xu, S. and Lam, K.P. (2001) Mol Cell Biol 21, 4067-74.
- Carpenter, R.O. et al. (2013) Clin Cancer Res 19, 2048-60.
- Tai, Y.T. et al. (2006) Cancer Res 66, 6675-82.
- Moreaux, J. et al. (2004) Blood 103, 3148-57.
- Tai, Y.T. et al. (2014) Blood 123, 3128-38.
限制使用
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For Research Use Only. Not For Use In Diagnostic Procedures.
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