Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

Protocol

Specificity / Sensitivity

TMEM175 (F5G5U) Rabbit mAb recognizes endogenous levels of total TMEM175 protein.

Species Reactivity:

Mouse, Rat

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of mouse TMEM175 protein.

Background

Transmembrane protein 175 (TMEM175) is a potassium channel located in the membrane of late endosomes and lysosomes. TMEM175 has been shown to regulate lysosomal membrane potential, pH stability, and organelle fusion. In contrast, TMEM175 deficiency impairs lysosomal pH stability, lysosome-mediated autophagosomal clearance, and mitochondrial clearance in cells (1). Dysfunctional mitophagy resulting from TMEM175 loss-of-function mutations has been implicated in several human central nervous system (CNS) diseases, including Alzheimer’s disease (AD) and Parkinson’s disease (PD) (2-4). Recently, it has been discovered that TMEM175 plays a role in apoptosis, as it is directly inhibited through binding of the anti-apoptotic regulator Bcl-2 (5).

Database Links

UniProt ID: Q9CXY1

Entrez-Gene Id: 72392

限制使用

除非 CST 的合法授书代表以书面形式书行明确同意，否书以下条款适用于 CST、其关书方或分书商提供的书品。任何书充本条款或与本条款不同的客书条款和条件，除非书 CST 的合法授书代表以书面形式书独接受，否书均被拒书，并且无效。

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For Research Use Only. Not For Use In Diagnostic Procedures.

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TMEM175 (F5G5U) Rabbit mAb #56936

Supporting Data

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Species Cross-Reactivity Key:

Product Information

Product Usage Information

Storage