R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.
TIMM17A (E6F3I) Rabbit mAb #45948
Filter:
- WB
- IP
Supporting Data
| REACTIVITY | H M R |
| SENSITIVITY | Endogenous |
| MW (kDa) | 18 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:100 |
Storage
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Protocol
Specificity / Sensitivity
TIMM17A (E6F3I) Rabbit mAb recognizes endogenous levels of total TIMM17A protein.
Species Reactivity:
Human, Mouse, Rat
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro160 of human TIMM17A protein.
Background
TIMM17A (mitochondrial import inner membrane translocase subunit Tim17-A) is a component of the TIM23 mitochondrial transport complex, the main translocase of mitochondrial matrix proteins (1). TIMM17A is a potential biomarker and therapeutic target in breast cancer, as high expression is associated with aggressiveness and poor prognosis (2-4). TIMM17A was identified as one of eleven genes included in a gene signature predictive of CDK4 phosphorylation, and of sensitivity to the CDK4/6 inhibitor Palbociclib (5).
限制使用
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For Research Use Only. Not For Use In Diagnostic Procedures.
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