Render Target: SSR
Render Timestamp: 2024-10-24T19:55:51.535Z
Commit: 56767fe525c928647c8401233a175d0d607d385d
XML generation date: 2024-09-17 16:01:11.960
Product last modified at: 2024-09-19T13:30:09.918Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77

Thyroid Transcription Factor 1 (TTF-1) (SPT24) Mouse mAb #23192

Filter:
  • IHC

    Supporting Data

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa)
    Source/Isotype Mouse IgG1
    Application Key:
    • IHC-Immunohistochemistry 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    IHC Leica Bond 1:100 - 1:400
    Immunohistochemistry (Paraffin) 1:50 - 1:200

    Storage

    Supplied as liquid tissue culture supernatant containing sodium azide as a preservative. Stable for 12 months when stored at 4°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    Thyroid Transcription Factor 1 (TTF-1) (SPT24) Mouse mAb recognizes endogenous levels of TTF-1 protein.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a recombinant protein corresponding to a 123 amino acid fragment of the N-terminal region of human TTF-1 protein.

    Background

    Thyroid Transcription Factor 1 (TTF-1, also known as NKX2-1), a member of the NKX homeobox transcription factor family, was initially discovered in the FRTL-5 rat thyroid cell line (1). Subsequent studies have shown that TTF-1 plays an important role in differentiation and morphogenesis of the developing thyroid, lung, and ventral forebrain (2). TTF-1 controls the expression of several genes, some of which are tissue specific, such as: thyroglobulin, thyroperoxidase, and the thyrotropin receptor in the thyroid; and surfactant proteins and clara cell secretory protein in the lung (2,3). Investigators have found that TTF-1 is expressed in malignant tumors of the thyroid and lung, and it is commonly used as a marker for both primary and malignant lung cancers (4-6).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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