Thy1 Antibody #9798
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Inquiry Info. # 9798
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Supporting Data
| REACTIVITY | H M R |
| SENSITIVITY | Endogenous |
| MW (kDa) | 22 |
| SOURCE | Rabbit |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:100 |
Storage
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Protocol
Specificity / Sensitivity
Thy1 Antibody recognizes endogenous levels of total Thy1 protein.
Species Reactivity:
Human, Mouse, Rat
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Thr66 of human Thy1 protein. Antibodies are purified by protein A and peptide affinity chromatography.
Background
The Thy1/CD90 cell surface antigen is a GPI-anchored, developmentally regulated protein involved in signaling cascades that mediate neurite outgrowth, T cell activation, tumor suppression, apoptosis, and fibrosis (1). Thy1/CD90 is highly expressed on the surface of adult neurons and is thought to play a role in modulating adhesive and migratory events, such as neurite extension (1,2). Decreased Thy1/CD90 mRNA and protein expression is associated with the development of epithelial ovarian cancer, suggesting a role as a putative tumor suppressor gene of human ovarian cancer (3,4). Research studies indicate that Thy1/CD90 knockout mice have impaired cutaneous immune responses and abnormal retinal development (5,6). Thy1/CD90 is epigenetically regulated or deregulated in some disease states, such as pulmonary fibrosis. The potentially reversible hypermethylation of the Thy1/CD90 promoter offers the possibility of novel therapeutic options in this disease (7).
- Rege, T.A. and Hagood, J.S. (2006) FASEB J 20, 1045-54.
- Barker, T.H. et al. (2004) Exp Cell Res 295, 488-96.
- Abeysinghe, H.R. et al. (2003) Cancer Genet Cytogenet 143, 125-32.
- Zeng, L.Q. et al. (2009) Zhonghua Zhong Liu Za Zhi 31, 118-20.
- Beissert, S. et al. (1998) J Immunol 161, 5296-302.
- Simon, P.D. et al. (1999) Brain Res Dev Brain Res 117, 219-23.
- Sanders, Y.Y. et al. (2008) Am J Respir Cell Mol Biol 39, 610-8.
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For Research Use Only. Not For Use In Diagnostic Procedures.
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