Thimet oligopeptidase (IVD6) Mouse mAb #4238
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Inquiry Info. # 4238
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Supporting Data
| REACTIVITY | H Mk |
| SENSITIVITY | Endogenous |
| MW (kDa) | 80 |
| Source/Isotype | Mouse IgG2b |
Application Key:
- WB-Western Blotting
- IHC-Immunohistochemistry
Species Cross-Reactivity Key:
- H-Human
- Mk-Monkey
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunohistochemistry (Paraffin) | 1:25 |
Storage
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Protocol
Specificity / Sensitivity
Thimet oligopeptidase (IVD6) Mouse mAb detects endogenous levels of total Thimet oligopeptidase protein.
Species Reactivity:
Human, Monkey
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues in the amino-terminal region of Thimet oligopeptidase protein.
Background
Amyloid beta precursor protein (APP) is a 100-140 kDa transmembrane glycoprotein containing the amyloid domain (A-beta). Beta-secretase is involved in proteolytic cleavage of APP releasing A-beta. The extracellular deposition and accumulation of the released A-beta fragments form the main components of amyloid plaques in Alzheimer's disease (1). Thimet oligopeptidase is a ubiquitously expressed metalloendopeptidase that was originally identified as a candidate beta-secretase (2). However, subsequent studies show that Thimet oligopeptidase promotes A-beta degradation. In addition, Thimet oligopeptidase inactivates a number of neuropeptides such as somatostatin, bradykinin, substance P and neurotensin (3). Finally, Thimet oligopeptidase has been shown both to increase and decrease presentation of antigenic peptides by the MHC-I at the cell surface. Despite these opposing results, there is consensus that Thimet oligopeptidase degrades peptides released by the proteasome (4-5).
限制使用
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For Research Use Only. Not For Use In Diagnostic Procedures.
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