STRIP1/FAM40A (E8J6I) Rabbit mAb #19325

STRIP1/FAM40A (family with sequence similarity 40, member A) is a component of the STRIPAK complex. STRIPAK is a multi-protein complex that plays important roles in various biological processes, particularly in cellular signaling, and regulates several signaling pathways that are critical for cellular processes such as cell proliferation, migration, and survival. It acts as a scaffold for various signaling proteins, facilitating their interactions and modulating their activities (1). The STRIPAK complex influences the organization and dynamics of the cytoskeleton, which is essential for maintaining cell shape, movement, and intracellular transport. It plays a role in establishing and maintaining cell polarity, which is crucial for proper cell function and tissue organization. The complex is implicated in the regulation of cell-cell adhesion, which is fundamental for tissue integrity and function (2). One of the major functions of the STRIPAK complex is to anchor and regulate the activity of PP2A, a serine/threonine protein phosphatase that dephosphorylates various proteins involved in signal transduction and cell cycle control. In the brain, the STRIPAK complex has been linked to neuronal development and synaptic function, playing a role in neural circuit formation and plasticity (2).