SOX11 (E7G9N) Rabbit mAb #58207

SRY-related high mobility group box (SOX) proteins comprise a large family of widely conserved transcription factors that play important roles in development. SOX proteins possess a high mobility group (HMG) motif that binds the DNA minor groove. SOX proteins typically do not mediate transcription directly, but require binding partners that regulate their ability to mediate transcription of target genes that control cell fate determination and development (reviewed in 1). SOX11 is generally described as a neural transcription factor, whose expression is critical for the establishment of neuronal identity in the embryonic mammalian brain (2). It has furthermore been reported to function as a pioneer transcription factor, able to bind nucleosomes and influence the transcription of genes in regions of closed chromatin, in similar fashion to its close relative SOX2 (3). Postnatal expression of SOX11 is reported to be uncommon, but aberrant SOX11 expression has been reported in numerous malignancies, including mantle cell lymphoma, Burkitt's lymphoma, and various lymphoblastic leukemias (4-6).