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  3. SLC44A1 (F8D3V) Rabbit mAb
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SLC44A1 (F8D3V) Rabbit mAb #65178

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  • WB
Western blot analysis of extracts from various tissues using SLC44A1/CTL1 (F8D3V) Rabbit mAb (upper) or β-Actin (D6A8) Rabbit mAb #8457 (lower).
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To Purchase # 65178

Cat. #

Size

Price

Inventory

65178T
20 µl
¥1,500

无库存

65178S
100 µl
¥4,990

无库存

Supporting Data

REACTIVITY H M R
SENSITIVITY Endogenous
MW (kDa) 60
Source/Isotype Rabbit IgG
Application Key:
  • WB-Western Blotting 
Species Cross-Reactivity Key:
  • H-Human 
  • M-Mouse 
  • R-Rat 
  • Related Products

Product Information

Product Usage Information

Application Dilution
Western Blotting 1:1000

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

Protocol

Specificity / Sensitivity

SLC44A1/CTL1 (F8D3V) Rabbit mAb recognizes endogenous levels of total SLC44A1/CTL1 protein. This antibody detects a 300 kDa protein of unknown identity in some cell lines.


Species Reactivity:

Human, Mouse, Rat

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro612 of human SLC44A1/CTL1 protein.

Background

Solute carrier family 44 member 1 (SLC44A1), also known as choline transporter-like protein 1 (CTL1), is a high-affinity choline transporter. SLC44A1/CTL1 is a member of the SLC44A family of transporters that may function to transport choline across the cell membrane (1). SLC44A1/CTL1, a membrane protein with nine transmembrane domains, is the only SLC44A family member firmly established as an Na+-independent choline transporter (2). SLC44A1/CTL1 is widely expressed in the nervous system in both neurons and oligodendrocytes. Choline transport into the cell is important for acetylcholine synthesis at cholinergic nerve endings. Moreover, choline is important for the synthesis of phospholipids that make up cell membranes. Abnormal choline transport and metabolism are implicated in several neurodegenerative diseases, and SLC44A1/CTL1, specifically, is genetically linked to a rare childhood-onset neurodegenerative disease characterized by various forms of cognitive and physical deficiencies (3,4). 

Database Links

UniProt ID: Q8WWI5


Entrez-Gene Id: 23446


限制使用

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For Research Use Only. Not For Use In Diagnostic Procedures.
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