R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.
RPL19 (F9Z9N) Rabbit mAb #94730
Filter:
- WB
Supporting Data
| REACTIVITY | H M R Mk |
| SENSITIVITY | Endogenous |
| MW (kDa) | 25 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
- Mk-Monkey
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Protocol
Specificity / Sensitivity
RPL19 (F9Z9N) Rabbit mAb recognizes endogenous levels of total RPL19 protein.
Species Reactivity:
Human, Mouse, Rat, Monkey
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val55 of human RPL19 protein.
Background
Ribosomal protein L19 (RPL19) is part of the ribosomal large 60S subunit. It is conserved in eukaryotes and archaea but is not present in bacteria (1-3). Like many other ribosomal proteins, it is critically important in cellular function, and many RPL19 pseudogenes are present throughout the genome (4). RPL19 is co-amplified along with HER2 in breast cancer (5). When highly expressed, RPL19 has been shown to be a poor prognostic marker in prostate and colorectal cancers and has been identified as a novel tumor antigen in lung adenocarcinoma (6-8).
- Wool, I.G. et al. (1995) Biochem Cell Biol 73, 933-47.
- Yang, D. et al. (1999) Mol Phylogenet Evol 12, 177-85.
- Chan, Y.L. et al. (1987) J Biol Chem 262, 1111-5.
- Shiran, A. et al. (1990) Biochem Int 22, 921-8.
- Dressman, M.A. et al. (2003) Cancer Res 63, 2194-9.
- Bee, A. et al. (2006) Clin Cancer Res 12, 2061-5.
- Huang, C.J. et al. (2008) J Cell Mol Med 12, 1936-43.
- Kuroda, K. et al. (2010) Cancer Sci 101, 46-53.
限制使用
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For Research Use Only. Not For Use In Diagnostic Procedures.
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