RORα (E6G5I) Rabbit mAb #34639

Retinoic acid-receptor (RAR)-related orphan receptor alpha (RORα) is an orphan nuclear receptor that, along with RORβ and RORγ, can bind to DNA as monomers. The N-terminus is alternatively spliced, resulting in isoforms that have various DNA binding properties (1). Activation of target genes by RORα is opposed by Rev-erb and NCoR (2). RORα has been implicated in many distinct biological functions. RORα regulates networks during Purkinje cell development, and its deletion causes the staggerer phenotype in mouse models (3). These mice display thin, long bones versus wild-type counterparts, as RORα is expressed in mesenchymal stem cells from bone marrow (4). RORα also upregulates IκBα, resulting in the inhibition of Nf-κB p65 and the inflammation response (5). RORα and RORγ facilitate the differentiation of T helper 17 cells, which mediate tissue inflammation (6). Also, RORα can promote myoblast differentiation by interacting with p300 and MyoD (7). Additionally, RORα plays a role in circadian rhythm by controlling key genes such as BMAL1 (8).