PYY (D1K3Q) Rabbit mAb #24895

Peptide tyrosine-tyrosine (PYY; also known as Peptide YY) is a short amino acid peptide that is a member of the gastrointestinal (GI) family of hormones (1). Other GI hormone family members include glucagon-like peptide-1 (GLP-1), ghrelin, cholecytokinin (CCK), leptin, glucose, and insulin. GI hormones have diverse physiological and behavioral functions, but some are part of the brain-gut axis that combines neural functions with the gut to regulate appetite and satiety. This subset of hormones is expressed in enteroendocrine cells, specialized cells of the GI tract and pancreas that are part of the enteric endocrine system. PYY, as well as GLP-1, is secreted by a specific group of enteroendocrine cells, L cells, which line parts of the ileum and colon. At least two endogenous forms of PYY exist: full length PYY (1-36) and cleavage-generated PYY (3-36). Ectopic peripheral injection of PYY (3-36) suppresses food intake and reduces weight gain (2). Systemic PYY (3-36) is likely to regulate food intake, in part, by regulation of hypothalamus-mediated homeostasis via arcuate nucleus (Arc)-expressed neuropeptide Y2 receptor (Y2R) (2, 3). Thus, Peptide YY is an important GI hormone that regulates Arc-expressed neuropeptide Y2R to inhibit feeding in the gut-hypothalamic pathway.