R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.
PVR/CD155 (D3G7H) Rabbit mAb #13544
Filter:
- WB
Supporting Data
| REACTIVITY | H Mk |
| SENSITIVITY | Endogenous |
| MW (kDa) | 60-80 glycosylated 45-50 nonglycosylated |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
- Mk-Monkey
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Protocol
Specificity / Sensitivity
PVR/CD155 (D3G7H) Rabbit mAb recognizes endogenous levels of total PVR (CD155) protein. Based on the protein sequence, this antibody is expected to recognize the α, β, γ, and δ isoforms of PVR (CD155) protein.
Species Reactivity:
Human, Monkey
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Arg172 of human PVR (CD155) protein.
Background
Poliovirus receptor (PVR), also known as CD155 and nectin-like 5 (Necl-5), is an immunoglobulin-like, transmembrane glycoprotein originally described as a mediator of poliovirus attachment to cells and later identified as important in adherens junction formation. PVR binds nectin-3 and interacts with integrin αvβ3 and PDGFR to regulate integrin clustering and focal contact formation at the leading edge of migrating cells (1,2). Research studies demonstrate that PVR and nectin-3 regulate contact inhibition during cell motility and proliferation in transformed 3T3 cells (3). Additional research indicates that PVR expression may play a role in the invasiveness of lung adenocarcinoma (4,5). In the immune system, CD155 plays a role in natural killer (NK) cell-mediated cytotoxicity (6).
- Takai, Y. et al. (2008) Nat Rev Mol Cell Biol 9, 603-15.
- Sakisaka, T. et al. (2007) Curr Opin Cell Biol 19, 593-602.
- Minami, Y. et al. (2007) Biochem Biophys Res Commun 352, 856-60.
- Tane, S. et al. (2013) Exp Mol Pathol 94, 330-5.
- Nakai, R. et al. (2010) Cancer Sci 101, 1326-30.
- Stanietsky, N. and Mandelboim, O. (2010) FEBS Lett 584, 4895-900.
限制使用
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For Research Use Only. Not For Use In Diagnostic Procedures.
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