PTPN14 (D5T6Y) Rabbit mAb #13808

Tyrosine-protein phosphatase non-receptor type-14 (PTPN14, Pez, PTPD2 and PTP36) is an evolutionarily conserved non-membrane tyrosine phosphatase with homology to the band 4.1 family of proteins (1-3). The PTPN14 protein contains an amino-terminal FERM (4.1-ezrin-radixin-moesin) domain, which suggests plasma membrane localization of the protein, and a carboxy-terminal protein tyrosine phosphatase (PTP) domain (4). Research studies have identified possible roles for PTPN14 in multiple, diverse signaling pathways, including cell growth and proliferation, cell migration and adhesion, and development. The PTPN14 phosphatase regulates the subcellular localization of YAP in a cell density-dependent manner, indicating a role for PTPN14 in the Hippo signaling pathway (5). The Drosophila PTPN14 homolog Pez localizes to adherens junctions, where it may regulate cell motility through dephosphorylation of β-catenin (3). PTPN14 may play a role in epithelial-mesenchymal transition through effects on the TGF-β signaling pathway (6), and interacts with VEGFR3, a receptor tyrosine kinase involved in lymphangiogenesis (7). Loss-of-function mutations in the PTPN14 gene are associated with colorectal cancer (8), and choanal atresia and lymphedema, an autosomal recessive disorder characterized by defects in both nasal passage development and lymphangiogenesis (7).