R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.
PTGDS (F5R5O) Rabbit mAb #41743
Filter:
- WB
Supporting Data
| REACTIVITY | H R |
| SENSITIVITY | Endogenous |
| MW (kDa) | 25 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
- R-Rat
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Simple Western™ | 1:10 - 1:50 |
Storage
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Protocol
Specificity / Sensitivity
PTGDS (F5R5O) Rabbit mAb recognizes endogenous levels of total PTGDS protein.
Species Reactivity:
Human, Rat
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val30 of human PTGDS protein.
Background
Prostaglandin D2 synthase (PTGDS), also known as lipocalin-type prostaglandin-D synthase (L-PGDS), catalyzes the conversion of prostaglandin H2 (PGH2) to prostaglandin D2 (PGD2) (1,2). Studies show that senescent cells have increased levels of oxylipins. The levels of PTGDS mRNA, which is involved in oxylipin biosynthesis, are also elevated in some senescent cells (3). In addition, the gene encoding this enzyme in mice was identified as a genetic marker for temperature-sensitive neurons in the preoptic area of anterior hypothalamus (POA). This enzyme is critical for thermoregulation, and when the temperature rises in mouse POA, it generates more PGD2 in temperature-sensitive neurons, reducing core body temperature (2).
限制使用
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For Research Use Only. Not For Use In Diagnostic Procedures.
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