R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.
PSD93 (D4Z4D) Rabbit mAb #19046
Filter:
- WB
- IP
Supporting Data
| REACTIVITY | H M R |
| SENSITIVITY | Endogenous |
| MW (kDa) | 110 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:50 |
Storage
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Protocol
Specificity / Sensitivity
PSD93 (D4Z4D) Rabbit mAb recognizes endogenous levels of total PSD93 protein.
Species Reactivity:
Human, Mouse, Rat
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro321 of human PSD93 protein.
Background
Postsynaptic Density Protein 93 (PSD93) is a member of the PSD subfamily of the membrane-associated guanylate kinase (PSD-MAGUK) proteins. Structurally, it most closely resembles PSD95, consisting of an N-terminal variable segment followed by three PDZ domains, an SH3 domain, and an inactive guanylate kinase (GK) domain (1,2). PSD93 is expressed in neuronal cells and located at the synapse where it interacts with neuronal receptors and proteins including the NMDA receptor (2-4), K+ channels (5,6), and the AMPA receptor (7) to regulate their membrane localization and neuronal signaling. Research studies have implicated PSD93 in postsynaptic related persistent pain induction, making PSD93 a potential target for treatment of this syndrome (3).
- Brenman, J.E. et al. (1996) J Neurosci 16, 7407-15.
- Kim, E. et al. (1996) Neuron 17, 103-13.
- Tao, Y.X. et al. (2003) J Neurosci 23, 6703-12.
- Niethammer, M. et al. (1996) J Neurosci 16, 2157-63.
- Kim, E. et al. (1995) Nature 378, 85-8.
- Leyland, M.L. and Dart, C. (2004) J Biol Chem 279, 43427-36.
- Elias, G.M. et al. (2006) Neuron 52, 307-20.
限制使用
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For Research Use Only. Not For Use In Diagnostic Procedures.
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