POM121 Antibody #83525
Filter:
- WB
Supporting Data
| REACTIVITY | H M R Mk |
| SENSITIVITY | Endogenous |
| MW (kDa) | 150 |
| SOURCE | Rabbit |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
- Mk-Monkey
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Protocol
Specificity / Sensitivity
POM121 Antibody recognizes endogenous levels of total POM121 protein. This antibody detects all POM121 protein variants, including POM121A, POM121B, and POM121C.
Species Reactivity:
Human, Mouse, Rat, Monkey
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human POM121 protein. Antibodies are purified by peptide affinity chromatography.
Background
The nuclear pore complex (NPC) is a multi-subunit protein channel that spans the nuclear envelope and is responsible for the nucleocytoplasmic trafficking of RNA, proteins, and ribonucleoproteins (1,2). POM121, also referred to as nucleoporin Nup121, is a transmembrane nuclear protein that is an essential component of the NPC. POM121 expression is increased in aggressive, lethal prostate cancer and contributes to cancer progression and aggressiveness by enhancing the nuclear import of oncogenic transcription factors, such as E2F1, MYC, and GATA2, allowing for the upregulation of target genes (3). Elevated levels of POM121 have also been associated with poor outcome in patients with colorectal, lung, and laryngeal cancers, and it may serve as a prognostic biomarker for these cancer types (4-6).
- Raices, M. and D'Angelo, M.A. (2017) Curr Opin Cell Biol 46, 26-32.
- Xu, S. and Powers, M.A. (2009) Semin Cell Dev Biol 20, 620-30.
- Rodriguez-Bravo, V. et al. (2018) Cell 174, 1200-1215.e20.
- Wang, T. et al. (2020) Expert Rev Mol Diagn 20, 345-353.
- Zhang, S. et al. (2020) Genet Test Mol Biomarkers 24, 819-824.
- Zhao, R. et al. (2020) Histol Histopathol 35, 1285-1293.
限制使用
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For Research Use Only. Not For Use In Diagnostic Procedures.
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