Cat. # | Size | Price | Inventory |
---|---|---|---|
94113S | 1 Kit |
REACTIVITY | H M R Mk |
Product Includes | Quantity | Isotype | |||
---|---|---|---|---|---|
mTOR (L7E6) Mouse mAb (BSA and Azide Free) | 100 µg | Mouse IgG2b | |||
Phospho-mTOR (Ser2448) (D28E11) Rabbit mAb (BSA and Azide Free) | 100 µg | Rabbit IgG |
Product Information
The Phospho-mTOR (Ser2448) Matched Antibody Pair is ideal for use with immunoassay technologies and high-throughput ELISA platforms requiring antibody pairs with specialized or custom antibody labeling. Labels include fluorophores, lanthanides, biotin, and beads. Platforms requiring conjugated Matched Antibody Pairs include MSD, Quanterix Simoa, Alpha Technology (AlphaScreen, AlphaLISA, LANCE, HTRF), and Luminex.
Learn how Matched Antibody Pairs move your projects forward, faster at cst-science.com/matched-antibody-pairs.
The mammalian target of rapamycin (mTOR, FRAP, RAFT) is a Ser/Thr protein kinase (1-3) that functions as an ATP and amino acid sensor to balance nutrient availability and cell growth (4,5). When sufficient nutrients are available, mTOR responds to a phosphatidic acid-mediated signal to transmit a positive signal to p70 S6 kinase and participate in the inactivation of the eIF4E inhibitor, 4E-BP1 (6). These events result in the translation of specific mRNA subpopulations. mTOR is phosphorylated at Ser2448 via the PI3 kinase/Akt signaling pathway and autophosphorylated at Ser2481 (7,8). mTOR plays a key role in cell growth and homeostasis and may be abnormally regulated in tumors. For these reasons, mTOR is currently under investigation as a potential target for anti-cancer therapy (9).
Explore pathways related to this product.
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