Cat. # | Size | Price | Inventory |
---|---|---|---|
86078S | 1 Kit |
REACTIVITY | H M |
Product Includes | Quantity | Isotype | |||
---|---|---|---|---|---|
Insulin Receptor β (L55B10) Mouse mAb (BSA and Azide Free) | 100 µg | Mouse IgG1 | |||
Phospho-IGF-I Receptor β (Tyr1135/1136)/Insulin Receptor β (Tyr1150/1151) (19H7) Rabbit mAb (BSA and Azide Free) | 100 µg | Rabbit IgG |
Product Information
Insulin receptor (InsR) is a heterodimeric membrane receptor tyrosine kinase. It is comprised of an extracellular α-subunit containing the ligand binding domain, and a β-subunit containing an extracellular domain, a transmembrane domain, and a cytoplasmic tyrosine kinase domain (1). Binding of insulin to InsR results in receptor autophosphorylation, and subsequent tyrosine kinase activation (2). This provides a docking site for various adaptor molecules, including insulin receptor substrate (IRS), Gab and Shc, phosphorylation of which promotes subsequent activation of multiple downstream signaling pathways including MAPK, PI3K, and TC10 (3,4). These events lead to increased glucose uptake and metabolism, and can promote cell growth. Loss-of-function mutation or desensitization of the InsR are two major contributors to insulin resistance and Type 2 diabetes (5).
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