R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.
PGLYRP-1/PGRP-S (E3B6M) Rabbit mAb #19360
Filter:
- F
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | |
| Source/Isotype | Rabbit IgG |
Application Key:
- F-Flow Cytometry
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Flow Cytometry (Fixed/Permeabilized) | 1:100 - 1:400 |
Storage
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Protocol
Specificity / Sensitivity
PGLYRP-1/PGRP-S (E3B6M) Rabbit mAb recognizes endogenous levels of total PGLYRP-1/PGRP-S protein.
Species Reactivity:
Human
Source / Purification
Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the amino terminus of human PGLYRP-1/PGRP-S protein.
Background
The human peptidoglycan recognition protein (PGRP) family is composed of four independent genes named for the relative length of their translated product. Human PGRP family proteins are soluble pattern-recognition receptors of the innate immune response that bind peptidoglycan and Gram-positive bacteria, and have direct bactericidal activity (1,2). PGRP-short (PGRP-S), also known as PGLYRP-1 and Tag7, is 196 amino acids (aa) in length (3). PGLYRP-1/PGRP-S is a secreted glycoprotein expressed by neutrophils that participates in killing phagocytized bacteria (4,5). PGLYRP-1/PGRP-S also has been shown to form a stable cytotoxic complex with the heat shock protein Hsp70 to induce tumor cell death (6,7). PGRP-long (PGRP-L), also known as PGLYRP-2, is 576 aa long. PGLYRP-2/PGRP-L is an N-acetylmuramoyl-L-alanine amidase that hydrolyzes bacterial peptidoglycan (8,9). PGRP-intermediate alpha, also known as PGLYRP-3, and PGRP-intermediate beta, also known as PGLYRP-4, are 341 aa and 373 aa long, respectively. PGLYRP-3 and PGLYRP-4 are co-expressed in the same cells and are exclusively secreted as homo- or heterodimers with antibacterial function (10).
- Dziarski, R. and Gupta, D. (2006) Cell Microbiol 8, 1059-69.
- Liu, C. et al. (2001) J Biol Chem 276, 34686-94.
- Kang, D. et al. (1998) Proc Natl Acad Sci U S A 95, 10078-82.
- Liu, C. et al. (2000) J Biol Chem 275, 24490-9.
- Dziarski, R. et al. (2003) Blood 102, 689-97.
- Yashin, D.V. et al. (2015) J Biol Chem 290, 21724-31.
- Yashin, D.V. et al. (2016) Biochimie 123, 32-6.
- Gelius, E. et al. (2003) Biochem Biophys Res Commun 306, 988-94.
- Wang, Z.M. et al. (2003) J Biol Chem 278, 49044-52.
- Lu, X. et al. (2006) J Biol Chem 281, 5895-907.
限制使用
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For Research Use Only. Not For Use In Diagnostic Procedures.
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