PCP4 Antibody #66282
Filter:
- WB
Supporting Data
| REACTIVITY | M R |
| SENSITIVITY | Endogenous |
| MW (kDa) | 12, 15 |
| SOURCE | Rabbit |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- M-Mouse
- R-Rat
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Protocol
Specificity / Sensitivity
PCP4 Antibody recognizes endogenous levels of total PCP4 protein.
Species Reactivity:
Mouse, Rat
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala36 of mouse PCP4 protein. Antibodies are purified by protein A and peptide affinity chromatography.
Background
Purkinje cell protein 4 (PCP4), also known as calmodulin regulator protein and brain-specific polypeptide, is a calmodulin (CaM)-binding protein. PCP4 binds to both calcium-free and calcium-bound CaM (1). PCP4 regulates calmodulin activity and may play a role in neuronal differentiation through activation of calmodulin-dependent kinase signaling. PCP4 was originally discovered in Purkinje cells of the cerebellum (2). In addition to the cerebellum, PCP4 is expressed in the hippocampus and cortex of the adult rodent brain (3). PCP4 may regulate neurite outgrowth and neurotransmitter release, and its expression levels may be altered in several neurodegenerative diseases, including Alzheimer’s disease (4).
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For Research Use Only. Not For Use In Diagnostic Procedures.
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