R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.
PARP2 (F3Z6Z) Rabbit mAb #20009
Filter:
- WB
Supporting Data
| REACTIVITY | H Mk |
| SENSITIVITY | Endogenous |
| MW (kDa) | 66 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
- Mk-Monkey
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Protocol
Specificity / Sensitivity
PARP2 (F3Z6Z) Rabbit mAb recognizes endogenous levels of total PARP2 protein.
Species Reactivity:
Human, Monkey
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro318 of human PARP2 protein.
Background
Protein ADP-ribosylation plays critical roles in various processes, such as the DNA damage response, chromatin organization, and transcriptional regulation, and is catalyzed by the poly (ADP-ribose) polymerase (PARP) family of proteins (1-3). Namely, PARP1, PARP2, and PARP3 play important roles in the repair of DNA strand breaks (4,5). Growing evidence has shown that PARP2 plays diverse regulatory roles in processes that include genomic stability and cell cycle regulation (6). More specifically, PARP2 has also been shown to contribute to heterochromatin reorganization in endodermal differentiation (7), and loss of PARP2 in mouse erythroid progenitors leads to cell cycle arrest at the G2/M transition (8).
- Gibson, B.A. and Kraus, W.L. (2012) Nat Rev Mol Cell Biol 13, 411-24.
- Posavec Marjanović, M. et al. (2017) Semin Cell Dev Biol 63, 102-113.
- Wei, H. and Yu, X. (2016) Genomics Proteomics Bioinformatics 14, 131-139.
- Martin-Hernandez, K. et al. (2017) Semin Cell Dev Biol 63, 92-101.
- Pascal, J.M. and Ellenberger, T. (2015) DNA Repair (Amst) 32, 10-16.
- Ali, S.O. et al. (2016) Am J Cancer Res 6, 1842-1863.
- Quénet, D. et al. (2008) FASEB J 22, 3853-65.
- Farrés, J. et al. (2015) Cell Death Differ 22, 1144-57.
限制使用
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For Research Use Only. Not For Use In Diagnostic Procedures.
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