R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.
OMG (F9N5O) Rabbit mAb #96946
Filter:
- WB
Supporting Data
| REACTIVITY | H M R |
| SENSITIVITY | Endogenous |
| MW (kDa) | 70-140 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Protocol
Specificity / Sensitivity
OMG (F9N5O) Rabbit mAb recognizes endogenous levels of total OMG protein.
Species Reactivity:
Human, Mouse, Rat
Source / Purification
Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the amino terminus of human OMG protein.
Background
Oligodendrocyte-myelin glycoprotein (OMG or OMgp) is a glycosylphosphatidylinositol (GPI)-linked membrane protein expressed in oligodendrocytes and myelin in the central nervous system (CNS) (1,2). OMG is a potent inhibitor of neurite outgrowth expressed in the late stages of myelination (3,4). It has been shown that this inhibitory effect occurs through interaction with Nogo receptor (NgR) and its associated complex; thus, disruption of this interaction may be a target for axonal recovery after injury (5). Altered levels of OMG protein have been seen in cerebrospinal fluid of patients with frontotemporal dementia and Alzheimer’s disease, implicating OMG in neurodegenerative diseases (6,7). OMG has also been implicated as a potential autoantigen in CNS inflammatory diseases such as acute disseminated encephalomyelitis and multiple sclerosis (8).
- Mikol, D.D. and Stefansson, K. (1988) J Cell Biol 106, 1273-9.
- Mikol, D.D. et al. (1990) J Cell Biol 110, 471-9.
- Kottis, V. et al. (2002) J Neurochem 82, 1566-9.
- Vourc'h, P. et al. (2003) Brain Res Dev Brain Res 144, 159-68.
- Wang, K.C. et al. (2002) Nature 417, 941-4.
- Remnestål, J. et al. (2020) Transl Neurodegener 9, 27.
- Górska, A.M. et al. (2024) J Neurosci Methods 411, 110239.
- Gerhards, R. et al. (2020) Acta Neuropathol Commun 8, 207.
限制使用
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For Research Use Only. Not For Use In Diagnostic Procedures.
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