Render Target: SSR
Render Timestamp: 2024-11-21T21:40:55.982Z
Commit: 5c4accf06eb7154018ba3f54329c7590f97f534a
XML generation date: 2024-08-01 15:28:39.386
Product last modified at: 2024-05-30T07:02:40.243Z
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PDP - Template Name: Polyclonal Antibody
PDP - Template ID: *******59c6464

Nucleostemin Antibody #9495

Filter:
  • WB

Inquiry Info. # 9495

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    Supporting Data

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 65
    SOURCE Rabbit
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    Nucleostemin Antibody recognizes endogenous levels of total nucleostemin protein.

    Species Reactivity:

    Human

    The antigen sequence used to produce this antibody shares 100% sequence homology with the species listed here, but reactivity has not been tested or confirmed to work by CST. Use of this product with these species is not covered under our Product Performance Guarantee.

    Species predicted to react based on 100% sequence homology:

    Mouse, Monkey

    Source / Purification

    Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human nucleostemin protein. Antibodies are purified by protein A and peptide affinity chromatography.

    Background

    Nucleostemin (GNL3) is a member of the MMR1/HSR1 GTP-binding protein family. It is essential in early embryogenesis (1) and investigators have shown that nucleostemin participates in the control of stem and cancer cell cycle proliferation (2), possibly through regulation of p53 activity (3). Nucleostemin has been found to be expressed in CNS stem cells, embryonic stem cells, and several cancer cell lines, and is localized to both the nucleus and the nucleolus in a cell-cycle dependent manner (4).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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