Nectin-4/PVRL4 (E5Q1W) Rabbit mAb #41798
- WB
Supporting Data
REACTIVITY | H |
SENSITIVITY | Endogenous |
MW (kDa) | 62, 75 |
Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
Application | Dilution |
---|---|
Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
The antigen sequence used to produce this antibody shares 100% sequence homology with the species listed here, but reactivity has not been tested or confirmed to work by CST. Use of this product with these species is not covered under our Product Performance Guarantee.
Species predicted to react based on 100% sequence homology:
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Thr283 of human Nectin-4/PVRL4 protein.
Background
Nectin-4/poliovirus receptor-related 4 (PVRL4) is a type-I transmembrane glycoprotein that belongs to the immunoglobulin superfamily and promotes cell-cell adhesion by serving as a major component of adherens junctions (1-3). The extracellular domain of Nectin-4, which contains an Ig variable-like domain (V) and two Ig constant-like domains (C), mediates binding to the measles virus (4) and to neighboring cells through trans heterophilic interactions with Nectin-1 (5,6). Unlike other nectin family members, which are widely expressed in adult tissues, Nectin-4 expression in humans is largely restricted to the placenta (7). Research studies have demonstrated that Nectin-4 is overexpressed in a variety of human solid tumors of the pancreas (8), breast (9,10), lung (11), and ovary (12). Due to its restricted expression pattern in normal human tissues, Nectin-4 may serve as a novel diagnostic and therapeutic target for a variety of human tumors.
- Takai, Y. et al. (2008) Annu Rev Cell Dev Biol 24, 309-42.
- Takai, Y. and Nakanishi, H. (2003) J Cell Sci 116, 17-27.
- Harrison, O.J. et al. (2012) Nat Struct Mol Biol 19, 906-15.
- Mühlebach, M.D. et al. (2011) Nature 480, 530-3.
- Mateo, M. et al. (2014) J Virol 88, 14161-71.
- Fabre, S. et al. (2002) J Biol Chem 277, 27006-13.
- Reymond, N. et al. (2001) J Biol Chem 276, 43205-15.
- Nishiwada, S. et al. (2015) J Exp Clin Cancer Res 34, 30.
- Lattanzio, R. et al. (2014) Oncogenesis 3, e118.
- Fabre-Lafay, S. et al. (2007) BMC Cancer 7, 73.
- Takano, A. et al. (2009) Cancer Res 69, 6694-703.
- Nabih, E.S. et al. (2014) Biomarkers 19, 498-504.
限制使用
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