NCX1 (D3F3H) Rabbit mAb #79350

NCX1 (Na⁺/Ca²⁺ exchanger, isoform 1) belongs to a conserved family of sodium-calcium membrane antiporter proteins that play a fundamental role in regulating intracellular calcium levels (1). NCX1 facilitates transmembrane transport of Ca²⁺ ions in exchange for Na⁺ ions in response to electrochemical gradients (2). Due to its relatively low affinity for calcium, NCX1 most commonly functions to export Ca²⁺ under acute conditions of high intracellular Ca²⁺. Notably however, NCX1 is a reversible antiporter, and can thus facilate Ca²⁺ influx under specialized physiological circumstances (3). Research studies have shown that NCX1 is particularly important for regulating intracellular Ca²⁺ levels in excitatory cell types (e.g., neurons, cardiac muscle). For example, conditional knockout of NCX1 in mouse cardiac pacemaker cells identified a critical role for NCX1 in the initiation and maintenance of cardiac rhythm (4).