R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.
NCR3/NKp30 (F3O3Q) Rabbit mAb #87214
Filter:
- WB
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 25-50 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Protocol
Specificity / Sensitivity
NCR3/NKp30 (F3O3Q) Rabbit mAb recognizes endogenous levels of total NCR3/NKp30 protein.
Species Reactivity:
Human
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu86 of human NCR3/NKp30 protein.
Background
The family of natural cytotoxicity receptors (NCRs) contains NCR1 (NKp46/CD335), NCR2 (NKp44/CD336), and NCR3 (NKp30/CD337). They are single-pass type I transmembrane proteins belonging to the immunoglobin (Ig) superfamily. Various pathogen-derived as well as host-encoded molecules have been identified as ligands for the NCRs. They were originally identified by their ability to evoke the cytotoxicity of natural killer (NK) cells toward tumor cells in vitro, and animal models have demonstrated that NCRs play a role in vivo in tumor surveillance, viral infection, and pregnancy (1-5).
NCR3/NKp30 is constitutively expressed in NK cells and at low levels in subpopulations of CD8+ cytotoxic T lymphocytes and γδ T cells (6, 7). NCR3/NKp30 is being investigated as a target for immunotherapies due to its role in mediating NK cell antitumor effects (8).
NCR3/NKp30 is constitutively expressed in NK cells and at low levels in subpopulations of CD8+ cytotoxic T lymphocytes and γδ T cells (6, 7). NCR3/NKp30 is being investigated as a target for immunotherapies due to its role in mediating NK cell antitumor effects (8).
- Sivori, S. et al. (1997) J Exp Med 186, 1129-36.
- Kruse, P.H. et al. (2014) Immunol Cell Biol 92, 221-9.
- Pazina, T. et al. (2017) Front Immunol 8, 369.
- Barrow, A.D. et al. (2019) Front Immunol 10, 909.
- Meza Guzman, L.G. et al. (2020) Cancers (Basel) 12, 952.
- Correia, M.P. et al. (2018) Proc Natl Acad Sci U S A 115, E5980-E5989.
- Correia, D.V. et al. (2011) Blood 118, 992-1001.
- Pinheiro, P.F. et al. (2020) Br J Pharmacol 177, 4563-4580.
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For Research Use Only. Not For Use In Diagnostic Procedures.
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