R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.
MZB1 (E8V4N) Rabbit mAb #96905
Filter:
- WB
Supporting Data
| REACTIVITY | H M |
| SENSITIVITY | Endogenous |
| MW (kDa) | 20 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Protocol
Specificity / Sensitivity
MZB1 (E8V4N) Rabbit mAb recognizes endogenous levels of total MZB1 protein.
Species Reactivity:
Human, Mouse
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu113 of human MZB1 protein.
Background
Marginal zone B- and B1-cell-specific protein (MZB1) is an ER-resident chaperone protein that is expressed by marginal zone B cells and during plasma cell differentiation (1,2). MZB1 possesses oxidoreductase activity that assists in the proper folding, assembly, and secretion of mature IgM by plasma cells (1,3). Research studies have demonstrated that loss of MZB1 expression compromises antibody secretion and humoral immune responses (4).
限制使用
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For Research Use Only. Not For Use In Diagnostic Procedures.
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KARPAS cell line source: Dr. Abraham Karpas at the University of Cambridge.
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