MYST3 Antibody #78462
Filter:
- WB
- ChIP
Supporting Data
| REACTIVITY | H Mk |
| SENSITIVITY | Endogenous |
| MW (kDa) | 320 |
| SOURCE | Rabbit |
Application Key:
- WB-Western Blotting
- ChIP-Chromatin Immunoprecipitation
Species Cross-Reactivity Key:
- H-Human
- Mk-Monkey
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Chromatin IP | 1:50 |
Storage
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Protocol
Specificity / Sensitivity
MYST3 Antibody recognizes endogenous levels of total MYST3 protein.
Species Reactivity:
Human, Monkey
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val1341 of human MYST3 protein. Antibodies are purified by protein A and peptide affinity chromatography.
Background
MYST3, also known as monocytic leukemia zinc finger protein (MOZ) and lysine acetyltransferase 6A (KAT6A), is a member of the MYST (MOZ, YBF2, SAS2, and TIP60) family of histone acetyltransferases (1,2). First discovered as a fusion partner of CREBBP in acute myeloid leukemia, MYST3 contributes to Hox gene expression and segment identity during development (3-6). MYST3 forms an evolutionarily conserved complex with ING5, EAF6, and BRD1 and has been shown to be a coactivator for many different transcription factors, including PU.1, NRF2, and Runx family members (7-9). MYST3 is critical in hematopoietic stem cell maintenance, where it acts synergistically with polycomb member BMI1 (10). Inhibitors of MYST3 are being investigated for therapeutic value as they can induce senescence and decrease tumor growth (11).
- Yang, Y. et al. (2014) Front Med 8, 79-83.
- Li, X. and Dou, Y. (2010) Epigenetics 5, 185-8.
- Borrow, J. et al. (1996) Nat Genet 14, 33-41.
- Champagne, N. et al. (2001) Oncogene 20, 404-9.
- Crump, J.G. et al. (2006) Development 133, 2661-9.
- Voss, A.K. et al. (2009) Dev Cell 17, 674-86.
- Katsumoto, T. et al. (2006) Genes Dev 20, 1321-30.
- Ohta, K. et al. (2007) Biochem J 402, 559-66.
- Bristow, C.A. and Shore, P. (2003) Nucleic Acids Res 31, 2735-44.
- Sheikh, B.N. et al. (2017) Exp Hematol 47, 83-97.
- Baell, J.B. et al. (2018) Nature 560, 253-7.
限制使用
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For Research Use Only. Not For Use In Diagnostic Procedures.
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