MXRA8 (E7K5Q) Rabbit mAb #56572

MXRA8 (Matrix remodeling-associated protein 8), also known as DICAM or limitrin, is a dual immunoglobulin domain containing cell adhesion molecule expressed on epithelial, myeloid, and mesenchymal cells. A single-pass type I transmembrane protein that is highly expressed at areas of cell-cell contact and may localize to tight junctions, MXRA8 mediates cell adhesion via interaction with αVβ3 integrin (1). Through its interactions with integrins, MXRA8 has been shown to suppress both angiogenesis (2) and osteoclast differentiation (3) in vitro by attenuating p38 mitogen-activated protein (MAP) kinase signaling. MXRA8 also plays a pivotal role in ferroptosis and the immune microenvironment of glioma, suggesting that it may serve as a novel prognostic marker and therapeutic target (4). A recent study showed that multiple emerging arthritogenic alphaviruses, including CHIKV, RRV, MAYV, and ONNV, use MXRA8 as a functional receptor (5). Structural insights into how Chikungunya virus particles bind MXRA8 to enhance viral attachment and internalization into cells may provide a guide for developing antiviral therapies against arthritogenic alphaviruses (6).