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Product Name

85652 Musashi (D46A8) Rabbit mAb

Filter:

WB

Inquiry Info. # 5663

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Supporting Data

REACTIVITY	H M R
SENSITIVITY	Endogenous
MW (kDa)	35
Source/Isotype	Rabbit IgG

Application Key:

WB-Western Blotting

Species Cross-Reactivity Key:

H-Human
M-Mouse
R-Rat

Product Information

Product Usage Information

Application	Dilution
Western Blotting	1:1000

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

Protocol

Specificity / Sensitivity

Musashi-1 (D46A8) Rabbit mAb detects endogenous levels of total Musashi-1 protein.

Species Reactivity:

Human, Mouse, Rat

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Met190 of human Musashi-1 protein.

Background

Musashi-1 and Musashi-2 are RNA-binding proteins which play a role in asymmetric cell division of ectodermal precursor cells by regulating the translation of target mRNA. Both family members augment Notch signaling and repress the translation of m-Numb, a protein that positively modulates differentiation of neural stem cells into neurons. Thus, Musashi contributes to the maintenance of neural stem cells (1). While Musashi-1 is frequently used as a marker for proliferating neural precursor cells, it is also expressed in epithelial stem cells including intestinal and mammary gland stem cells (2-4).

Database Links

UniProt ID: O43347

Entrez-Gene Id: 4440

限制使用

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For Research Use Only. Not For Use In Diagnostic Procedures.

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Musashi-1 (D46A8) Rabbit mAb #5663