MT-ATP8 Antibody #17412
Filter:
- WB
- IP
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 9 |
| SOURCE | Rabbit |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:50 |
Storage
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Protocol
Specificity / Sensitivity
MT-ATP8 Antibody recognizes endogenous levels of total MT-ATP8 protein.
Species Reactivity:
Human
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human MT-ATP8 protein. Antibodies are purified by peptide affinity chromatography.
Background
Mitochondrially-encoded ATP Synthase Membrane Subunit 8 (MT-ATP8) is a product of MT-ATP8, one of 13 protein-encoding genes in the human mitochondrial genome (1). MT-ATP8 comprises one subunit (ATP synthase FO subunit 8) of mitochondrial ATP synthase (Complex V), the inner mitochondrial enzyme that catalyzes the final step of oxidative phosphorylation in the electron transport chain (2). Numerous mutations in MT-ATP8 have been identified that have deleterious effects on ATP synthase function, some of which manifest as debilitating neuronal and/or neuromuscular diseases, including epilepsy, schizophrenia, autism, ataxia, and various cardiomyopathies (3), underscoring the importance of healthy mitochondrial function to organismal health.
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For Research Use Only. Not For Use In Diagnostic Procedures.
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