MT-ATP6 Antibody #70262
Filter:
- WB
- IP
Supporting Data
| REACTIVITY | H M R |
| SENSITIVITY | Endogenous |
| MW (kDa) | 20 |
| SOURCE | Rabbit |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:50 |
Storage
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Protocol
Specificity / Sensitivity
MT-ATP6 Antibody recognizes endogenous levels of total MT-ATP6 protein.
Species Reactivity:
Human, Mouse, Rat
Source / Purification
Polyclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human MT-ATP6 protein. Antibodies are purified by peptide affinity chromatography.
Background
Mitochondrially-encoded ATP Synthase Membrane Subunit 6 (MT-ATP6) is a product of MT-ATP6, one of 13 protein-encoding genes in the mitochondrial genome. MT-ATP6 comprises one subunit of the transmembrane F1FO ATP synthase (Complex V), which catalyzes the final step of oxidative phosphorylation in the electron transport chain (1). Numerous mutations in the MT-ATP6 gene have been identified that lead to defects in oxidative phosphorylation. Many of these are strongly associated with distinct disease states, including Leigh syndrome (2) and Charcot-Marie-Tooth (CMT) disease (3).
限制使用
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For Research Use Only. Not For Use In Diagnostic Procedures.
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