Render Target: SSR
Render Timestamp: 2024-11-14T22:52:45.510Z
Commit: 3c1f305a63297e594ac8d7bb5424007d592d68be
XML generation date: 2024-09-30 01:57:50.075
Product last modified at: 2024-10-24T14:15:12.120Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

MS4A4A (E7J5D) Rabbit mAb #29717

Filter:
  • WB
  • IP

    Supporting Data

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 25
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:100

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    MS4A4A (E7J5D) Rabbit mAb recognizes endogenous levels of total human MS4A4A protein.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala228 of human MS4A4A protein.

    Background

    Membrane-spanning 4-domains subfamily A member 4A (MS4A4A) is a member of a class of MS4A genes encoding four-transmembrane-spanning proteins (1,2). MS4A4A expression is enriched in human and mouse macrophages (3,4). Its expression in macrophages may be induced during macrophage development and activation (4). MS4A4A, via its interaction with the β-glucan receptor, Dectin-1, may contribute to macrophage-mediated production of proinflammatory cytokines and reactive oxygen species by activation of the Syk signaling pathway (4). Interestingly, MS4A4A, as well as other members of the MS4A gene cluster, is genetically linked to late-onset Alzheimer’s disease, suggesting that MS4A4A-dependent macrophage/microglia might contribute to neurodegenerative disease progression (5,6).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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