R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.
MEX3C (D5T2Z) Rabbit mAb #50844
Filter:
- WB
Supporting Data
| REACTIVITY | H M R |
| SENSITIVITY | Endogenous |
| MW (kDa) | 80 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Protocol
Specificity / Sensitivity
MEX3C (D5T2Z) Rabbit mAb recognizes endogenous levels of total MEX3C protein.
Species Reactivity:
Human, Mouse, Rat
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala54 of human MEX3C protein.
Background
MEX3C is an RNA-binding E3 ubiquitin ligase implicated in a diverse set of biological functions.
Along with PIGN and ZNF516, MEX3C has been identified as a suppressor of chromosome instability (CIN), which drives intratumor heterogeneity and has been associated with poor prognosis in colon cancer. Silencing of the Mex3c gene induces chromosome instability through replication stress/impaired replication fork progression (1).
In mice, absence of the Mex3c gene causes growth retardation and reduced insulin-like growth factor 1 (IGF1) expression (2). Researchers have shown that murine MEX3C plays a role in controlling energy expenditure, physical activity and degree of adiposity (3,4). In the immune system, MEX3C is involved in post-transcriptional regulation of HLA-A2 (5), and plays a role in eliciting antiviral response (6).
Along with PIGN and ZNF516, MEX3C has been identified as a suppressor of chromosome instability (CIN), which drives intratumor heterogeneity and has been associated with poor prognosis in colon cancer. Silencing of the Mex3c gene induces chromosome instability through replication stress/impaired replication fork progression (1).
In mice, absence of the Mex3c gene causes growth retardation and reduced insulin-like growth factor 1 (IGF1) expression (2). Researchers have shown that murine MEX3C plays a role in controlling energy expenditure, physical activity and degree of adiposity (3,4). In the immune system, MEX3C is involved in post-transcriptional regulation of HLA-A2 (5), and plays a role in eliciting antiviral response (6).
- Burrell, R.A. et al. (2013) Nature 494, 492-6.
- Jiao, Y. et al. (2012) Mol Biol Cell 23, 1404-13.
- Jiao, Y. et al. (2012) Mol Cell Biol 32, 4350-62.
- Han, C. et al. (2014) J Endocrinol 221, 457-68.
- Cano, F. et al. (2012) EMBO J 31, 3596-606.
- Kuniyoshi, K. et al. (2014) Proc Natl Acad Sci U S A 111, 5646-51.
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For Research Use Only. Not For Use In Diagnostic Procedures.
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