MCT1/SLC16A1 Antibody #85680
Filter:
- WB
Supporting Data
REACTIVITY | H |
SENSITIVITY | Endogenous |
MW (kDa) | 43 |
SOURCE | Rabbit |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
Application | Dilution |
---|---|
Western Blotting | 1:1000 |
Storage
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Protocol
Specificity / Sensitivity
MCT1/SLC16A1 Antibody recognizes endogenous levels of total human MCT1/SLC16A1 protein.
Species Reactivity:
Human
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly472 of human MCT1/SLC16A1 protein. Antibodies are purified by peptide affinity chromatography.
Background
MCT1, also known as MOT1, is a multi-pass transmembrane monocarboxylate transporter (MCT) protein, encoded by the gene SLC16A1 (1,2). MCT1 is reported to be expressed in multiple tissues and cell types, including erythrocytes, immune cells, and both cardiac and skeletal myocytes. The primary role of MCT1 is to facilitate proton-coupled transport of monocarboxylates (e.g., lactate, pyruvate, ketone bodies) across the plasma membrane in response to cellular metabolic demands (1). The regulation of monocarboxylate flux by MCT1 has been identified as a possible metabolic biomarker in various diseases, including neurodegenerative diseases, ischemia, and cancer (2-5). Inhibition of MCT1 has thus been proposed as a potential therapeutic treatment of cancer (5,6).
- Halestrap, A.P. (2012) IUBMB Life 64, 1-9.
- Payen, V.L. et al. (2020) Mol Metab 33, 48-66.
- Pérez-Escuredo, J. et al. (2016) Biochim Biophys Acta 1863, 2481-97.
- Tasdogan, A. et al. (2020) Nature 577, 115-120.
- Afonso, J. et al. (2019) Cell Oncol (Dordr) 42, 303-318.
- Khan, A. et al. (2020) Oncogene 39, 3555-3570.
限制使用
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For Research Use Only. Not For Use In Diagnostic Procedures.
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