MAP1S (E3P5Z) Rabbit mAb #57187

MAP1S is a member of the microtubule-associated protein (MAP) family. There are at least ten proteins in the MAP family, including MAP1A, MAP1B, MAP1S, MAP2, MAP6, MAP7, MAP9, Tau, DCLK, and DCX. MAP1 subfamily members express predominantly in brain cells regulating several physiological processes in cells, including cytoskeleton regulation that, in some cases are energy-dependent, including the autophosphorylation and phosphorylation of other MAP family members, and other cytoskeletal proteins (1,2). MAP1 family members have been identified as high-molecular-weight proteins consisting of the full-length (FL), at least one heavy chain (HC), one light chain (LC), and, in some members short chains (SC) (2,3). The FL-MAP1S is formed by the HC and LC, forming the active MAP1S complex. The LC binds, bundles, and stabilizes microtubules, and the HC regulates LC activity (2). MAP1S also interacts with Nemitin (neuronal enriched MAP interacting protein), enhancing cytoskeleton regulation (4).

MAP1S contributes to mitochondria stabilization by interacting with mitochondrion-associated leucine-rich PPR-motif containing protein (LRPPRC). MAP1S regulates ubiquitination processes like autophagosome biogenesis and protein clearance. These processes are MAP1S isoform-specific (5). An increased level of MAP1S enhances autophagy to remove p62-associated aggresomes and dysfunctional organelles that trigger DNA double-strand breaks and genome instability (6).