MALT1 Antibody #2494
Filter:
- WB
- IP
Supporting Data
| REACTIVITY | H M R |
| SENSITIVITY | Endogenous |
| MW (kDa) | 90 |
| SOURCE | Rabbit |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:50 |
Storage
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Protocol
Specificity / Sensitivity
MALT1 Antibody detects endogenous levels of total MALT1 protein.
Species Reactivity:
Human, Mouse, Rat
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the carboxy terminus of mouse and rat MALT1 protein. Antibodies are purified by protein A and peptide affinity chromatography.
Background
Mucosa-associated lymphoid tissue translocation gene 1 (MALT1) is a paracaspase that is a critical mediator of T-cell receptor activation of NF-κB and may contribute to the progression of MALT lymphomas (1-4). It contains two immunoglobulin-like domains, an amino-terminal death domain and a carboxy-terminal caspase-like domain. Association of MALT1 with Bcl-10 and CARD11/Carma1 leads to activation of IKK and subsequent stimulation of NF-κB, resulting in increased proliferation and inhibition of apoptosis (5,6). A common translocation in MALT B-cell non-Hodgkin lymphomas t(11;18)(q21;q21) results in the fusion of the amino terminus of API2 (c-IAP2), a member of the inhibitor of apoptosis protein family, to the carboxy terminus of MALT1 (1,2). The API2-MALT1 fusion protein likely leads to deregulation of NF-κB, contributing to increased oncogenic potential (7).
- Akagi, T. et al. (1999) Oncogene 18, 5785-5794.
- Uren, A.G. et al. (2000) Mol. Cell 6, 961-967.
- Ruland, J. et al. (2003) Immunity 19, 749-758.
- Nakagawa, M. et al. (2006) Leukemia 20, 929-936.
- Che, T. et al. (2004) J. Biol. Chem. 279, 15870-15876.
- Lucas, P.C. et al. (2001) J. Biol. Chem. 276, 19012-19019.
- Ho, L. et al. (2005) Blood 105, 2891-2899.
限制使用
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For Research Use Only. Not For Use In Diagnostic Procedures.
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