R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.
MAD2L2 (F9H9U) Rabbit mAb #98423
Filter:
- WB
- IP
Supporting Data
| REACTIVITY | H M R |
| SENSITIVITY | Endogenous |
| MW (kDa) | 24 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Simple Western™ | 1:50 - 1:250 |
| Immunoprecipitation | 1:100 |
Storage
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Protocol
Specificity / Sensitivity
MAD2L2 (F9H9U) Rabbit mAb recognizes endogenous levels of total MAD2L2 protein.
Species Reactivity:
Human, Mouse, Rat
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val203 of human MAD2L2 protein.
Background
Mitotic arrest deficient 2 like 2 (MAD2L2), also known as REV7, is a Mad family mitotic spindle assembly checkpoint protein that regulates progression into anaphase of mitosis (1), and functions in translesion DNA synthesis and DNA double-strand break (DSB) repair (2). MAD2L2 expression is high in human cancer, and expression levels are correlated with prognosis. MAD2L2 expression may predict the effectiveness of chemotherapy and PARP inhibitors, and MAD2L2 inhibitors may enhance the effects of these treatments (3).
限制使用
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For Research Use Only. Not For Use In Diagnostic Procedures.
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