Render Target: SSR
Render Timestamp:
4/3/2025, 3:11:47 PM EDT
4/3/2025, 7:11:47 PM UTC
Commit: 070ddbed3d58ff00053de84939cefdd328876779
XML generation date: 2025-03-07 13:17:32.948
Product last modified at: 2025-01-31T17:15:09.022Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

LAPTM5 (E7D5O) Rabbit mAb #83820

Filter:
  • WB
  • IHC

    Supporting Data

    REACTIVITY M
    SENSITIVITY Endogenous
    MW (kDa) 15, 25
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IHC-Immunohistochemistry 
    Species Cross-Reactivity Key:
    • M-Mouse 

    Product Information

    Product Usage Information

    Application Dilution
    Immunohistochemistry (Paraffin) 1:500 - 1:2000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    LAPTM5 (E7D5O) Rabbit mAb recognizes endogenous levels of total LAPTM5 protein.

    Species Reactivity:

    Mouse

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro246 of mouse LAPTM5 protein.

    Background

    Lysosomal-associated transmembrane protein 5 (LAPTM5) is a multi-pass transmembrane protein expressed in late endosomal/lysosomal compartments of hematopoietic cells (1). LAPTM5 contains three PY motifs (L/PPxY) and a ubiquitin-interacting motif (UIM). Transport of LAPTM5 to appropriate subcellular compartments requires LAPTM5 binding to the ubiquitin-ligase Nedd4 (2). Although the function of LAPTM5 remains unknown, it may function in immune cells to transport other molecules to be released from the lysosome once at the plasma membrane. Interestingly, the gene that encodes LAPTM5 was identified as an amyloid plaque-induced gene (PIG) that is upregulated in microglia of mouse models of Alzheimer’s disease (AD), suggesting that LAPTM5 may play a role in AD pathogenesis (3). 
    For Research Use Only. Not For Use In Diagnostic Procedures.
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